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Ferreira FS, Biasibetti-Brendler H, Pierozan P, Schmitz F, Bert CG, Prezzi CA, Manfredini V, Wyse ATS (2018) Kynurenic acid restores Nrf2 levels and prevents quinolinic acid-induced toxicity in rat striatal slices

The unique pathological microenvironment of DWincluding persistently high ROS levels, high protease activity, and pH fluctuationsposes significant challenges to drug stability, retention, and bioactivity